One small molecule inhibitor, Rhosin (Shang et al., 2012), inhibits RHOA signaling by directly targeting the RHOA protein, in breast and hepatocellular cancer cells (Shang et al., 2012; Lin and Zheng, 2015; Olson, 2018), as well as GC cells (Yoon et al., 2016). This evidence concerns the gene RHOA and hepatocellular carcinoma.