The RHO GTPase enzyme family, including RHOA, Rac, and cdc42, is essential for diverse biological processes, including cell morphology phenotypes, cell polarity, and cell migration, in diverse cancer types (Etienne-Manneville and Hall, 2002; Hanna and El-Sibai, 2013; Lin and Zheng, 2015; Haga and Ridley, 2016; Woldu et al., 2018). Here, RHOA is linked to cancer.