Due to a scarcity of RHOA reviews in the field of gastric cancer (GC), our focus herein is limited to RHOA, and its related GTPase family members (Etienne-Manneville and Hall, 2002; Heasman and Ridley, 2008; Hanna and El-Sibai, 2013; Haga and Ridley, 2016; Woldu et al., 2018) in GC. The gene discussed is RHOA; the disease is gastric cancer.