For example, recently, a contradictory role for RHOA, in two Lauren diffuse type GC cell lines (HSC-59, GSU) of 17 GC cell lines (12 for diffuse type and five for intestinal type), was suggested, in that low RHOA protein expression, due to aberrant alternative splicing of RHOA transcripts, was found in the two GC cell lines (HSC-59, GSU) (Miyamoto et al., 2018). This evidence concerns the gene RHOA and gastric cancer.