In HCC, tumor genes such as procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3), and splicing factor 3b subunit 4 (SF3B4) are overexpressed in HCC tumor tissues compared with adjacent tissues, and knocking down their expression levels can effective suppress tumor invasion (Shen et al., 2018). Here, PLOD3 is linked to neoplasm.