Intravenous administration of CD73-specific small interfering RNA (siRNA)-loaded chitosan-lactate nanoparticles (ChLa NPs) potentiated the antitumor effects of a DC vaccine in 4T1 breast cancer-bearing mice, with augmented CTL effector function, improved T cell proliferations, and increased production of inflammatory cytokines (185). The gene discussed is NT5E; the disease is breast carcinoma.