PADI4 and nephritis: In harmony with these critical comments, Gordon et al. (96) demonstrated that NETs inhibition by different approaches, like genetically manipulated Nox-deficient mice, or by deletion of PADi4 or pharmacological inhibition of PAD4 activity hardly had any influence on nephritis, and NETs inhibition did not affect any aspects of nephritis, did not lead to loss of tolerance, nor to immune activation (96).