In addition, He et al reported that both miR-146a and b were involved in the regulation of macrophage activation and have a potential for treating schistosomiasis through regulating differentiation of macrophages (37), further demonstrating that only miR-146b could be induced by a series of Th2 cytokines to inhibit the differentiation of macrophages to M1 cells through targeting STAT1. This evidence concerns the gene STAT1 and schistosomiasis.