In smooth muscle cells (SMC), sublytic assault by MAC stimulates release of insulin-like growth factor-1 (57), whereas in glomerular epithelial cells it causes transactivation of the receptors for epidermal growth factor (EGF), human epidermal growth factor 2/Neu, fibroblast growth factor, and hepatocyte growth factor, all vital growth factors during tumor development (58). This evidence concerns the gene EGF and neoplasm.