RIPK3 and breast cancer: The meaning of the association between C5b-9 and necroptotic effectors has many nuances: RIPK3 and MLKL are in fact seen as putative tumor suppressors (70), but in vitro work in breast cancer cells has recently highlighted the contributions of the necroptotic genes RIPK1, RIPK3, and MLKL in promoting anchorage-independent tumor growth and mediating tumor cell resistance to radiation (71).