The proteins yielding the largest fold change between SLE patients and controls (p < 0.05), were interferon regulatory factor 5 (IRF5), solute carrier family 22 member 2 (SLC22A2, organic cation transporter 2, OCT2) and S100 calcium binding protein A12 (S100A12, Calgranulin-C) (Figure 2). This evidence concerns the gene IRF5 and systemic lupus erythematosus.