The medical importance of CB1R's broad distribution and influence over every aspect of energy homeostasis and metabolism, from the brain's hunger signals to nutrient utilization in the periphery, is highlighted by a 2015 review article (54) which designates the eCB system as a “pivotal orchestrator of obesity and metabolic disease” due to its “multi-organ energy-stowing function.” The juxtaposition of physiological energy balancing with metabolic pathologies echoes the central theme of this paper. The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.