NDST1 encodes a bifunctional GlcNAc N-deacetylase/N-sulfotransferase with important functions in biosynthesis of heparan sulfate, which play roles in triglyceride-rich lipoprotein clearance (27), stroke (28, 29), and allergic airway inflammation through the regulation of recruitment of inflammatory cells to the airways by mediating interaction of leukocytes with the vascular endothelium (30). The gene discussed is NDST1; the disease is Stroke.