CNTNAP2 and Isaacs syndrome: Some VGKCs antibodies were detected in Isaacs' syndrome, however, positivity of antibodies against VGKCs in the absence of antibodies to leucine-rich glioma inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) is not a clear disease biomarker for autoimmune inflammation and seems not to contribute in clinical practice (100).