Compared with CN and MCI participants, AD patients were more impaired on MMSE score and performed higher levels on CSF t-tau, p-tau, t-tau/ Aβ, p-tau/ Aβ, ADAS-cog 11, ADAS-cog 13, Global CDR, NPI-Q, and FAQ scores (p < 0.01). Here, MAPT is linked to Alzheimer disease.