This COMT polymorphism has been associated with several cognitive and emotional functions regulated by the prefrontal and parietal cortices, such as working memory (Goldberg et al., 2003; Mier et al., 2010; Júlio-Costa et al., 2014), numerical cognition (Tan et al., 2007; Júlio-Costa et al., 2013), impulsivity (Stein et al., 2006), anxiety (Mier et al., 2010; Gottschalk and Domschke, 2017), and psychiatric conditions such as schizophrenia (González-Castro et al., 2016), ADHD (Kebir and Joober, 2011; Bonvicini et al., 2016), autism (Nikolac Perkovic et al., 2014), etc. The gene discussed is COMT; the disease is Anxiety.