Thus, we evaluated the histology of pancreas from early-stage T1D mice and observed that the STZ+TUDCA mice presented increased beta-cell mass and beta-cell number per islet, suggesting that TUDCA may be able to partially recover beta-cell mass, which, together with the reduction in IDE activity and insulin clearance, results in an increased insulinemia and, consequently, improvement of glucose homeostasis in T1D mice. Here, INS is linked to type 1 diabetes mellitus.