Insulin therapy is usually associated with some side effects, such as hypoglycemia and weight gain (Dewitt and Hirsch, 2003; Bergenstal et al., 2010), which is aggravated by the lack of patient compliance with adequate treatment, since the condition is more common in children and adolescents (Hilliard et al., 2013; Hynes et al., 2016, 2017). This evidence concerns the gene INS and Hypoglycemia.