While Htt does not directly interact with BDNF, it does interact with many proteins involved in BDNF transport and signaling, and BDNF signaling through the TrkB receptor is reduced in HD (Zuccato and Cattaneo, 2007; Milnerwood and Raymond, 2010; Shirasaki et al., 2012; Plotkin and Surmeier, 2015; Saudou and Humbert, 2016). Here, BDNF is linked to Huntington disease.