Considering that Ten-3 expression has also been linked to reduced neuroblastoma malignancy, we hypothesize that Wnt3a/Wnt5a-mediated Ten-3 expression might be associated with the Wnt3a/Wnt5a context-dependent protective effects against neuroblastoma (Grossmann et al., 2013). This evidence concerns the gene TENM3 and neuroblastoma.