PGR and glioblastoma: Moreover, progesterone also promotes GBM tumor growth and infiltration in rats’ cerebral cortex in a xenograft model (Germán-Castelán et al., 2014, 2016), effects which are mainly mediated by the PR, given that they are partially blocked in GBM cells following the administration of mifepristone (González-Agüero et al., 2007; Germán-Castelán et al., 2014; Piña-Medina et al., 2016).