AKT1 and nervous system disorder: Kim et al. (2011) applied manual acupuncture at GB34 to activate the neuroprotective PI3K/Akt pathway. Along the same line of evidence, Lin et al. found that EA stimulation on GB34 and LR3 not only enhanced BDNF expression but also induced the activation of the signaling proteins Akt and ERK in MPP+-induced rat models (Lin et al., 2017). Acupoints such as GB34 (Yang Ling Quan), ST36 (Zu San Li) and GV20 (Bai Hui) are frequently selected to achieve neuroprotective properties. GV20 and GV29 are used as scalp acupuncture for neurological disorders (Lee et al., 2013).