Transactive response DNA binding protein 43 (TDP-43) phosphorylation, cytoplasmic translocation, and truncation are pathological hallmarks of FTLD and ALS, including C9-FTLD and C9-ALS (Cooper-Knock et al., 2012), and potential contributors to disturbed RNA metabolism (Gendron et al., 2010). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.