However, compared to neurons, RNA foci have only been detected in a small fraction of microglia and astrocytes in post-mortem C9-ALS frontal cortex (Mizielinska et al., 2013) and/or cerebellum of C9-HRE carrying FTLD, ALS and FTLD/ALS patients (DeJesus-Hernandez et al., 2017). Here, C9 is linked to amyotrophic lateral sclerosis.