Iba1-positive microglia of C9-ALS patient post-mortem motor cortex and spinal cord contained enlarged lysosomes based on LAMP1 immunoreactivity compared to sporadic ALS cases (O'Rourke et al., 2016), suggesting lysosomal alterations in C9-HRE carriers. The gene discussed is C9; the disease is amyotrophic lateral sclerosis.