-S100B in cortical and white matter of PS-1 and sporadic AD brains (Shepherd et al., 2006);-S100B in layer I cortex of AD brains (Simpson et al., 2010);-↑ S100B hippocampus, temporal lobe, frontal lobe and pons in AD brains (Van Eldik and Griffin, 1994). The gene discussed is S100B; the disease is Alzheimer disease.