-↑ S100A6 in white matter; in gray matter is concentrated in amyloid plaques of AD patients (Boom et al., 2004);-S100A6 in amygdala and hippocampus in APP/London mice (Boom et al., 2004);-↑ S100A6 expression in APP/PS1KI mice (Wirths et al., 2010; Weissmann et al., 2016). This evidence concerns the gene APP and Alzheimer disease.