As other S100 proteins, S100A6 is upregulated in AD patients and in AD mouse models (Boom et al., 2004; Wirths et al., 2010; Weissmann et al., 2016) and is found in astrocyte-positive clusters that surround Aβ amyloid deposits in the brain’s gray matter (Boom et al., 2004). This evidence concerns the gene S100A6 and Alzheimer disease.