-Associated with amyloid plaques (Shepherd et al., 2006);-Present in diffuse (non-neuritic) amyloid deposits (Mrak et al., 1996);-Overexpression of S100B ↑large plaques (Mori et al., 2010);-PSAPP/S100B-/-↓cortical amyloid plaque load and number (Roltsch et al., 2010);-S100B-positive astrocytes surround neuritic plaques (Van Eldik and Griffin, 1994). The gene discussed is S100B; the disease is amyloidosis.