ADAM10 and Alzheimer disease: Exogenous S100A7 in primary hippocampal neurons of Tg2576 AD transgenic embryos inhibits the generation of Aβ42 and Aβ40 peptides and promotes the activity of “non- amyloidogenic” α-secretase, via upregulation of ADAM-10 (a disintegrin and metalloproteinase) and phosphorylation of Erk1/2 and PKC (Qin et al., 2009).