PICALM and Alzheimer disease: In the past few years, many genetic variants associated with late-onset AD, such as APOE, BIN1, PICALM, PLD3, and NME8, have been identified to affect the process of AD pathology via modifying CSF Aβ1-42 and tau levels (Schjeide et al., 2011; Liu et al., 2014; Wang et al., 2015; Liu et al., 2016; Wang et al., 2016).