A missense mutation (rs3747742-C) in TREML2 exhibited the highest linkage disequilibrium (LD) with rs9381040, which is an inter-genic SNP between TREM2 and TREML2 showing association with AD risk in the International Genomics of Alzheimer’s Project (Lambert et al., 2013; Benitez et al., 2014). This evidence concerns the gene TREM2 and Alzheimer disease.