BMP1 and cancer: As BMP1 mRNA was upregulated in TCGA-KIRC database, we confirmed the protein level in ccRCC cancer tissues and cells with western blotting (Fig. 4a, b), two BMP1 shRNA plasmids were transfected into the A498 and Caki-1 cells, resulting in a consistent BMP1 knockdown (Fig. 4c, d), CCK-8 and transwell experimental experiments revealed that BMP1 knockdown inhibited the proliferation, cell migration, and invasion in A498 and Caki-1 cells (Fig. 4e, f).