Multiple studies comparing high-altitude individuals with and without chronic mountain sickness further identified additional genes that seem to protect against chronic disease at high altitude, including ANP32D (acidic nuclear phosphoprotein 32 family member D), SENP1 (SUMO-specific peptidase 1) and PRDM1 (PR/SET domain 1) [41,42]. This evidence concerns the gene PRDM1 and chronic mountain sickness.