ANXA1 and Stroke: Furthermore, the effects on platelets were also paralleled with increased stroke severity as displayed by increased neurological score, infarct volume, and BBB permeability in both the contralateral and ipsilateral hemispheres of tMCAo/R AnxA1−/− mice (Figure IC through IE in the online-only Data Supplement), suggesting that deletion of the AnxA1 gene is associated with increased neurovascular inflammation after cerebral I/RI.