ANXA1 and Stroke: Having provided clear evidence that deletion of AnxA1 is associated with increased platelet and PNA adherence after stroke (Figure 1) and administration of AnxA1 ameliorates the detrimental effects of I/RI by diminishing platelet interactions at the cerebral endothelium, we wanted to evaluate the contribution of AnxA1 on platelet activation/aggregation after cerebral I/RI.