Here, we questioned whether we could exploit the biological properties of AnxA1 and its receptor FPR2/ALX to instigate possible novel drug-discovery programs for anti-inflammatory, proresolving strategies suitable to treat cardiovascular diseases especially acute ischemic stroke.37,39 Hence, we began here by assessing whether AnxA1 played functional roles in cerebral I/RI. Here, FPR2 is linked to cardiovascular disorder.