Infections with CBSV ICs containing a deletion of the Ham1 sequence (CBSV_HKO), mutated SHR ITPase motif (CBSV_mutHam), and a UCBSV Ham1 chimera (CBSV_UHam) did not develop necrosis in N. benthamiana, but instead developed systemic leaf curling, chlorotic mottling, and stunting. Here, ITPA is linked to infection.