The potassium channel Kv1.3 was identified as a marker and regulator of pro-inflammatory DAM [13], and inhibition of Kv1.3 channels was found to be beneficial in Alzheimer’s disease models as well as in the transient middle cerebral artery occlusion (tMCAO) ischemic stroke model [13–15]. Here, KCNA3 is linked to early-onset autosomal dominant Alzheimer disease.