In addition, the overexpression of circTRIM33–12 or TET1 could increase the mRNA and protein expression levels of WWC3, TP53INP1, ULBP1 and JHDM1D in HCC SMMC-7721 cells (Fig. 6b; Additional file 6: Figure S6b). This evidence concerns the gene WWC3 and hepatocellular carcinoma.