To investigate whether circTRIM33–12 exerts its biological functions through the miR-191/TET1 axis, we examined the expression of WWC3, TP53INP1, ULBP1 and JHDM1D in HCC cells with circTRIM33–12 or TET1 knockdown and overexpression. The gene discussed is TET1; the disease is hepatocellular carcinoma.