To investigate whether circTRIM33–12 exerts its biological functions through the miR-191/TET1 axis, we examined the expression of WWC3, TP53INP1, ULBP1 and JHDM1D in HCC cells with circTRIM33–12 or TET1 knockdown and overexpression. This evidence concerns the gene TP53INP1 and hepatocellular carcinoma.