Both the silencing of circTRIM33–12 or TET1 significantly reduced the mRNA and protein expression levels of WWC3, TP53INP1, ULBP1 and JHDM1D in HCC Huh 7 cells (Fig. 6a; Additional file 6: Figure S6a). This evidence concerns the gene TP53INP1 and hepatocellular carcinoma.