The RNA-seq results showed that TET1 knockdown downregulated several tumor suppressor genes that participated in tumor progression, such as WWC family member 3 (WWC3), tumor protein p53 inducible nuclear protein 1 (TP53INP1), UL16 binding protein 1 (ULBP1) and lysine demethylase 7A (JHDM1D) (Additional file 7: Table S5). The gene discussed is TP53INP1; the disease is neoplasm.