AFP and hepatocellular carcinoma: The results demonstrate that HCC patients with circTRIM33–12low had larger tumor sizes (P = 0.022), multiple tumors (P = 0.028), encapsulation invasion (P = 0.007), elevated alphafetoprotein levels (AFP, P = 0.02), and microvascular invasion (P = 0.002) compared with those in HCC patients with circTRIM33–12high.