Additionally, Mdm2SNP309G/G mice crossed with mice containing the R172H TP53 hotspot mutation (p53515A/+) succumbed to tumors significantly faster than Mdm2SNP309T/T p53515A/+ mice (P = 0.0005) had significantly decreased overall survival (401 and 482 days, respectively) and developed multiple primary tumors, supporting SNP309G as a risk factor for cancer susceptibility (Post et al., 2010). This evidence concerns the gene TP53 and cancer.