The BET inhibitor OTX-015 and, to a greater extent, cisplatin caused dramatic decreases in the progression of S47 tumors in a xenograft model; interestingly, the ability of cisplatin to preferentially kill S47 tumor cells occurred in a transcription-independent manner, via the direct mitochondrial cell death pathway of p53 (Barnoud et al., 2018). The gene discussed is TP53; the disease is neoplasm.