TP53 and central nervous system cancer: Since its initial discovery in 2011, several other groups have independently confirmed the role of the PAS p53 allele in cancer, including glioma, neuroblastoma, and esophageal squamous cell carcinoma (Egan et al., 2012; Zhou et al., 2012; Enciso-Mora et al., 2013; Diskin et al., 2014).