Besides, leptin can promote the production of leukotrienes, increase the secretion of immune factor immunoglobulin E, and elevate the expression of inflammatory mediators, thus leading to airway inflammatory response.20 The shortcoming of this study was that our preliminary data should be further validated with a large number of samples and the exact mechanism pathway of adiponectin and leptin to exacerbate the asthma has not been determined, and it will be the emphasis in subsequent research. This evidence concerns the gene LEP and asthma.