KMT2A and acute myeloid leukemia: The greatest increase was observed for Jarid1b among the four increased demethylases; Jarid1b has been reported to negatively regulate LSC stem potential and leukaemogenesis in murine and human MLL‐rearranged AML cells.15 A global reduction in H3K4me3 levels may be a common feature in stem cell specification, where stem gene silencing results from the removal of H3K4me3 by demethylases.