OVOL1 and neoplasm: In skin melanoma, high expression of Ovol1 prevents tumour invasion and predicts a better prognosis than that associated with low expression.37 In cutaneous and oral SCC, the expression of Ovol1 markedly decreases in the invasive portion compared with the in situ state, implying a role of Ovol1 in potentiating differentiation.38, 39 Despite the importance in cell differentiation, the regulation of Ovol1 expression is largely unknown.