To clarify this hypothesis, we detected the expression levels of E-cadherin, vimentin, p65, p-p65, Bcl-2, BCL-XL and survivin and found that the expression levels of E-cadherin, vimentin, p65, p-p65, Bcl-2, BCL-XL and survivin were contrary in miR-873-5P or JMJD8 over-expressed CRC cells. The gene discussed is BCL2; the disease is colorectal carcinoma.