In the remaining two cases, p-tau pathologies appeared as 4R tau-positive, 3R tau-negative, neuronal cytoplasmic inclusions, neurites, coiled bodies, and tufted astrocytes, or as astrocytic plaques, ballooned cells, and pre-tangles, consistent with pathologic diagnoses of progressive supranuclear palsy (PSP) [23] or corticobasal degeneration (CBD), respectively [5]. The gene discussed is MAPT; the disease is progressive supranuclear palsy.