MAPT and early-onset autosomal dominant Alzheimer disease: Deposition of p-tau in a pattern and distribution fulfilling preliminary neuropathological criteria for CTE was present in eight cases, all but one of which also showed mixed p-tau and Aβ pathologies in keeping with Alzheimer’s disease neuropathologic changes (ADNC), with seven cases in total showing ‘high/intermediate’ ADNC and a single case with ‘low’ ADNC [33].