Moreover, analyzing gene expression data from 2,433 breast cancer patients using the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC)cohort (31), we found that SNAT2 mRNA abundance significantly correlated with the expression of many genes in our previously reported in vivo hypoxia signature (32), as well as with HIF-1α, but not with HIF-2α (EPAS), and the whole signature itself (SI Appendix, Fig. S6B). Here, EPAS1 is linked to breast cancer.