Additionally, data acquired during a previous study of a mouse model of the iron overload disease hemochromatosis, generated through a ubiquitous knock in (KI) of the fpnC326Y gene (which encodes a hepcidin-resistant FPN), revealed that FPN was markedly up-regulated in PASMCs compared with lungs from wild-type control mice (SI Appendix, Fig. S1A). The gene discussed is SLC40A1; the disease is hemochromatosis type 1.