In summary, we, for the first time, report that CRYAB and p53 expression is positively correlated in ovarian cancer, high CRYAB and p53 co-expression is an independent prognostic factor of DFS and OS, and patients with high CRYAB and p53 co-expression have the worst prognoses among ovarian cancer patients. The gene discussed is TP53; the disease is ovarian carcinoma.