GLA and Fabry disease: Fabry disease (FD) is an X-linked lysosomal storage disorder in which a deficiency in the enzyme alpha-galactosidase A [1] leads to a progressive accumulation of glycosphingolipids such as globotriaosylceramide (Gb3) and globotriaosylsphingosine (lyso-Gb3) in tissues across the body [2].