Their CLL related target genes includes BCL2/MCL1/CCND1/WNT3A [30], BAZ2A/RNF41/RASSF5/MKK3/LRIG1 [31] et al. The miR-15/107 was also strongly implicated in Alzheimer’s disease. The gene discussed is CCND1; the disease is early-onset autosomal dominant Alzheimer disease.