Some studies indicated that Cyfra21–1 was better than CEA as a predictor of OS for prognosis in ESCC [12, 18], Cao et al. found that Cyfra21–1 and SCC-Ag were both independently significant poor predictors of prognosis in patients with stage II ESCC [5]. This evidence concerns the gene CEACAM5 and esophageal squamous cell carcinoma.