So we infer that nucleotide substitutions such as rs2734648-GG, rs1799987-AA, rs1799988-CC and rs1800023 could associated with susceptibility to CIN by alternate nuclear factors binding,, then subsequently affect the efficiency of CCR5 translation and CCR5 expression level on cell surface and, finally, affect the development of cervical lesions. The gene discussed is CCR5; the disease is cervical squamous intraepithelial neoplasia.