Our results showed that haplotype H1: A-T-G-T-G-C, which was similar to CCR5-HHC, was the most-common haplotype in our participants and consisted of the major alleles of these 6 SNPs revealing a protective effect against CIN; and a tendency of susceptibility to CIN appeared in H2 (similar to CCR5-HHE), H3 (similar to CCR5-HHF) and H4 (similar to CCR5-HHA), although these haplotypes did not show statistical association with CIN. This evidence concerns the gene CCR5 and cervical squamous intraepithelial neoplasia.