In all patients experiencing hyperprogression, a specific subtype of CD163+ CD33+PD-L1+ macrophages with an epithelioid morphology was observed, and this was statistically more frequent than in non-hyperprogressive patients, defining a population of tumor-associated macrophages (TAM) that was enriched in patients with hyperprogression (p < 0.0001). This evidence concerns the gene CD274 and neoplasm.