We analyzed the LCN2 concentration in HSIL, CC cases, HPV-positive and HPV-negative controls and found that the LCN2 level was significantly higher in HPV-positive than in HPV-negative women (median 32,983 (25th–75th percentile, 10,008–41,140) pg/mL and 15,540 (25th–75th percentile, 1237–32,872) pg/mL, respectively; P = 0.029), but no difference was observed between HPV16/18 and other HPV types (Figure 4). The gene discussed is LCN2; the disease is cholangiocarcinoma.