A large-scale study has identified four SNPs in the 5′UTR of VEGF-A that were associated with a higher risk of bladder cancer: i) the TT genotype of Ex1-73C > T (rs25648); ii) the AA genotype of −15648A > C (rs833052); iii) the TT genotype of −9228G > T (rs1109324); and iv) the TT genotype of −8339A > T (rs1547651). The gene discussed is VEGFA; the disease is urinary bladder carcinoma.