A study of the triggering of coagulation cascade and inflammatory response by CRP in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) found that ANCA-induced netting neutrophils can prompt the formation of monomeric CRP from pentameric form, which can further accelerate thrombogenesis, enhance platelet activation and augment the inflammatory response. This evidence concerns the gene CRP and vasculitis.