Whereas, inhibition of VRAC with DCPIB (at higher concentrations than required to inhibit VRAC currents) in these latter GBM cell lines [28] and siRNA-mediated LRRC8A knockdown in U251 cells [40] was reported to reduce cell viability and proliferation, however, we did not observe such effect by either treatment in these cell lines. This evidence concerns the gene LRRC8A and glioblastoma.