Specific features include extra cell deposition of plaques of amyloid-beta (Aβ), intracellular accumulation of inclusions of hyperphosphorylated microtubule-binding tau in AD, intracellular storage of α-synuclein in PD, inclusion of TAR DNA-binding protein (TDP)-43 transactive response in ALS, frontotemporal dementia, and polyglutamine protein aggregates in HD and other repeat CAG-polyglutamine diseases. This evidence concerns the gene TARDBP and Alzheimer disease.