AKT1 and neoplasm: PTEN, located on chromosome site 10q23.3, is a tumor suppressor gene that encodes a 403-amino acid polypeptide, which is a dual lipid/protein phosphatase considered essential for tumor suppressor properties, since its phosphatase activity makes it a negative regulator of PI3K and Akt/mTOR signaling, and thus playing important roles in the regulation of apoptosis, cell cycle arrest, angiogenesis, adhesion and invasion, and DNA damage repair [9,10].