TP53 and central nervous system cancer: In our study, we found that 5 of 8 (62.5%) mutations in TP53 gene were localized into hotspot region, confirming the prevalence of mutations described in literature in this region; however, 3 mutations (37.5%) were present in exons 4, 10, and 11, thus showing the need for studying all exons of TP53 gene in gliomas.