It was also found here that colon cancer cells display different sensitivities to drugs and that they become resistant to them despite the combination with the lysosomotropic agent and the autophagy inhibitor hydroxychloroquine (HCQ), which has been reported to synergize with the mTOR inhibitor CCI-779 to suppress melanoma growth and to induce apoptotic cell death [11]. This evidence concerns the gene MTOR and melanoma.