NTRK1 and hereditary clear cell renal cell carcinoma: For instance, compound 2 contains an indazole ring that is also present in the kinase inhibitor entrectinib, currently in Phase II against NTRK/ROS1/ALK driven tumours, whereas the trans-3-ethylideneindolin-2-one group in compound 1 is also the hinge binding moiety in sunitinib, an inhibitor of receptor tyrosine kinases, currently on the market for the treatment of renal cell carcinoma and gastrointestinal stromal tumours.