For instance, compound 2 contains an indazole ring that is also present in the kinase inhibitor entrectinib, currently in Phase II against NTRK/ROS1/ALK driven tumours, whereas the trans-3-ethylideneindolin-2-one group in compound 1 is also the hinge binding moiety in sunitinib, an inhibitor of receptor tyrosine kinases, currently on the market for the treatment of renal cell carcinoma and gastrointestinal stromal tumours. This evidence concerns the gene ROS1 and hereditary clear cell renal cell carcinoma.