The difference in survival is accounted for by the more aggressive biological behaviour of RCRC liver metastases with higher rates of mutations in oncogenes such as RAS and BRAF and probably other factors associated with the histological subtype of primary tumour and surgical outcomes of simultaneous colonic resection that have not yet been analysed prospectively in detail by the oncosurgical scientific community. The gene discussed is BRAF; the disease is neoplasm.