Here, we studied the Lynx1 expression in human cells of epithelial origin (normal oral keratinocytes Het-1A, embryonic kidney cells HEK-293T, epidermoid carcinoma A431, breast adenocarcinoma MCF-7, lung adenocarcinoma A549 and colon carcinoma HT-29). This evidence concerns the gene LYNX1 and squamous cell carcinoma.