We use a novel “off-diagonal” CHI SQ algorithm to demonstrate our ability to select individuals demented solely by depression’s effect in both the Texas Alzheimer’s Research and Care Consortium (TARCC) (N ≌ 3,500), and the Alzheimer’s Disease Neuroimaging Initiative (ADNI (N ≌ 1,750), and demonstrate the higher resistin levels of such cases in TARCC. This evidence concerns the gene RETN and major depressive disorder.